Modafinil and unconstrained motor activity in schizophrenia
نویسندگان
چکیده
منابع مشابه
Modafinil and armodafinil in schizophrenia.
What Might Be the Positive Spin-Offs Associated With Modafinil or Armodafinil Use in This Patient? Racemic modafinil and its R-isomer armodafinil are approved treatments for the excessive daytime drowsiness associated with narcolepsy, shift work, and obstructive sleep apnea1; therefore, either of these drugs could benefit Mr P. In schizophrenia, modafinil and armodafinil have been prescribed, s...
متن کاملStructural brain correlates of unconstrained motor activity in people with schizophrenia.
Avolition affects quality of life in chronic schizophrenia. We investigated the relationship between unconstrained motor activity and the volume of key executive brain regions in 16 male patients with schizophrenia. Wristworn actigraphy monitors were used to record motor activity over a 20 h period. Structural magnetic resonance imaging brain scans were parcellated and individual volumes for an...
متن کاملQuantitative motor activity differentiates schizophrenia subtypes.
BACKGROUND Motor symptoms are frequent in schizophrenia and relevant to the diagnosis of subtypes. However, the assessment has been limited to observations recorded in scales and experimental designs. The aim of this study was to use wrist actigraphy to obtain motor activity data in 3 schizophrenia subtypes. METHODS In total, 60 patients with schizophrenia (35 paranoid, 12 catatonic, 13 disor...
متن کاملThe quantitative assessment of motor activity in mania and schizophrenia.
BACKGROUND Increased motor activity is a cardinal feature of the mania of Bipolar Disorder (BD), and is thought to reflect dopaminergic dysregulation. Motor activity in BD has been studied almost exclusively with self-report and observer-rated scales, limiting the ability to objectively quantify this behavior. We used an ambulatory monitoring device to quantify motor activity in BD and schizoph...
متن کاملModafinil induces wakefulness without intensifying motor activity or subsequent rebound hypersomnolence in the rat.
Modafinil, a novel compound for treating excessive sleepiness, potently increases wakefulness in laboratory rodents, cats, monkeys and humans. Although its mechanism of action is unknown, modafinil appears to be unlike classic stimulants. We investigated this generality by testing the selectivity of this compound for wake-promoting effects (e.g., relative to locomotor effects) and homeostatic s...
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ژورنال
عنوان ژورنال: British Journal of Psychiatry
سال: 2006
ISSN: 0007-1250,1472-1465
DOI: 10.1192/bjp.bp.105.017335